Response to platelet-derived growth factor

Across TCGA patient cohorts, RNA activity of the Response to platelet-derived growth factor pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABHD17AP4, GCDH, and MAN1A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to platelet-derived growth factor activity versus ABHD17AP4 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ABHD17AP4 →	+0.590	+0.168	<.001	<.001	3	3
LSCC	GCDH →	-0.410	-0.105	.001	.007	3	3
BRCA	MAN1A1 →	-1.072	-0.182	<.001	<.001	3	3
OV	NUDT8 →	+0.797	+0.173	<.001	<.001	3	3
GBM	RARRES1 →	-0.599	-0.156	.006	.007	3	3
BRCA	CTSG →	-0.968	-0.151	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036119 vs ABHD17AP4 — HNSC

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