Response to platelet-derived growth factor

Across TCGA cell cohorts, RNA activity of the Response to platelet-derived growth factor pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ6, GABARAP, and C2orf72, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to platelet-derived growth factor activity versus COQ6 in BREAST (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	COQ6 →	+0.594	+0.163	.007	.007	3	5
LUNG_SCLC	GABARAP →	+0.778	+0.218	.009	.002	3	4
SKIN	C2orf72 →	+1.370	+0.219	<.001	<.001	3	4
SKIN	SCARB1 →	+2.179	+0.247	<.001	.002	3	4
SKIN	TP53INP2 →	+1.673	+0.238	.003	.004	3	4
BONE	ZNF720 →	+0.808	+0.311	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036119 vs COQ6 — BREAST

Explore this scatter interactively →