Fatty-acyl-CoA catabolic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF500, MLC1, and SERPING1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF500 grouped by Fatty-acyl-CoA catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF500 →	-0.317	-0.129	.001	.002	3	5
BLOOD_Myeloma	MLC1 →	+0.670	+0.185	.002	.002	3	5
BLOOD_Leukemia	SERPING1 →	-0.169	-0.100	.005	.001	3	4
CNS	TMEM240 →	-0.234	-0.091	.009	<.001	3	4
OVARY	INS →	+0.181	+0.060	.001	.009	3	4
LUNG_SCLC	LAMB4 →	-0.342	-0.134	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF500 by Fatty-acyl-CoA catabolic process activity — LUNG_SCLC

Explore this box plot interactively →