Medium-chain fatty-acyl-CoA metabolic process

Across TCGA cell cohorts, RNA activity of the Medium-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT7, ICA1L, and ATE1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty-acyl-CoA metabolic process activity versus ACOT7 in LUNG_NSCLC_LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACOT7 →	+0.868	+0.200	.001	.003	3	6
LUNG_NSCLC_LUAD	ICA1L →	+0.500	+0.144	.005	.009	3	5
OVARY	ATE1 →	+0.868	+0.277	.001	.002	3	4
LUNG_NSCLC_LUSC	RBBP7 →	+1.020	+0.545	.002	.007	2	5
BONE	HSD17B4 →	+0.819	+0.317	.003	.001	3	4
BONE	SYAP1 →	+0.605	+0.260	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036112 vs ACOT7 — LUNG_NSCLC_LUAD

Explore this scatter interactively →