Alpha-linolenic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-linolenic acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FADS2, PRTFDC1, and TOP2A_S1213, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-linolenic acid metabolic process activity versus FADS2 in LUAD (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FADS2 →	+0.953	+0.080	<.001	<.001	3	6
OV	PRTFDC1 →	+0.601	+0.059	<.001	<.001	3	5
OV	TOP2A_S1213 →	+0.515	+0.045	<.001	.006	3	5
HNSC	MAP1B_S1208 →	+0.491	+0.077	.001	.003	3	5
UCEC	JMJD6 →	+0.236	+0.057	.002	.002	3	4
PDAC	TTLL12 →	-0.236	-0.043	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036109 vs FADS2 — LUAD

Explore this scatter interactively →