Leukotriene catabolic process

Across TCGA cell cohorts, RNA activity of the Leukotriene catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOA1, RNF40, and GSTA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOA1 grouped by Leukotriene catabolic process-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	APOA1 →	+0.168	+2.015	.001	<.001	3	4
CNS	RNF40 →	+0.238	+0.783	.003	.006	3	4
STOMACH	GSTA1 →	-0.127	-1.556	.003	.001	2	5
LIVER	AFDN →	-0.191	-1.513	.004	.001	3	3
BLOOD_Leukemia	NCAM1 →	-0.210	-1.446	<.001	<.001	3	3
STOMACH	MAN2A2 →	+0.158	+1.600	.007	.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOA1 by Leukotriene catabolic process activity — LARGE_INTESTINE

Explore this box plot interactively →