Phosphatidylinositol-3-phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phosphatidylinositol-3-phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC9A, LUARIS, and GTSF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol-3-phosphate biosynthetic process activity versus CLEC9A in CCRCC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CLEC9A →	+0.641	+0.867	<.001	<.001	3	4
CCRCC	LUARIS →	-0.301	-0.631	.002	.002	3	4
HNSC	GTSF1 →	+1.151	+0.530	<.001	.003	3	3
HNSC	SAPCD2 →	-0.837	-0.805	.006	.001	3	3
HNSC	LINC02000 →	+0.090	+0.692	.005	.004	3	3
HNSC	HMGB3 →	-0.874	-0.914	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036092 vs CLEC9A — CCRCC

Explore this scatter interactively →