Cleavage furrow formation

Across TCGA patient cohorts, RNA activity of the Cleavage furrow formation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PGM2, PMM2, and RPL13, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cleavage furrow formation activity versus PGM2 in BRCA (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PGM2 →	-0.287	-0.029	<.001	<.001	3	5
CCRCC	PMM2 →	-0.347	-0.063	<.001	<.001	3	5
COAD	RPL13 →	-0.193	-0.037	<.001	<.001	3	4
LSCC	ACTN4 →	+0.232	+0.044	.002	.001	3	4
GBM	BAZ1A →	+0.284	+0.048	.003	.001	3	4
GBM	WEE1_T173 →	+0.705	+0.048	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036089 vs PGM2 — BRCA

Explore this scatter interactively →