Cleavage furrow formation

Across TCGA patient cohorts, RNA activity of the Cleavage furrow formation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OAF, HSPB2, and MTIF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cleavage furrow formation activity versus OAF in UCEC (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OAF →	+0.594	+0.795	.008	.001	2	4
PDAC	HSPB2 →	+0.136	+0.505	.001	.007	3	3
GBM	MTIF3 →	-0.294	-0.666	<.001	<.001	3	3
LSCC	RPS7P1 →	-0.523	-0.253	<.001	.005	3	3
HNSC	MIR200C →	-0.651	-0.214	.007	.009	3	2
HNSC	RNU6-89P →	-0.584	-0.180	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036089 vs OAF — UCEC

Explore this scatter interactively →