Cleavage furrow formation

Across TCGA cell cohorts, RNA activity of the Cleavage furrow formation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NKAPD1, GATB, and CPSF4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cleavage furrow formation activity versus NKAPD1 in BLOOD_Myeloma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	NKAPD1 →	+1.162	+1.353	.008	.003	3	5
KIDNEY	GATB →	+0.969	+1.504	.005	<.001	3	4
PANCREAS	CPSF4 →	+0.672	+0.923	.003	.003	3	4
LUNG_NSCLC_LUAD	PLGLB2 →	-0.311	-0.573	.002	.005	3	4
LUNG_NSCLC_LUAD	PRRG4 →	+1.101	+0.491	<.001	.008	3	4
KIDNEY	NSMCE1 →	+0.642	+1.735	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036089 vs NKAPD1 — BLOOD_Myeloma

Explore this scatter interactively →