Response to erythropoietin

Across TCGA patient cohorts, RNA activity of the Response to erythropoietin pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPYD, MT1X, and MRPL28, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to erythropoietin activity versus DPYD in COAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DPYD →	+0.598	+0.050	<.001	<.001	3	7
LSCC	MT1X →	+0.783	+0.099	<.001	<.001	3	7
PDAC	MRPL28 →	-0.513	-0.059	<.001	.005	3	7
LSCC	STRBP →	-0.594	-0.104	<.001	<.001	3	7
COAD	GTPBP10 →	-0.535	-0.040	<.001	<.001	3	7
LSCC	MRPS14 →	-0.397	-0.099	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036017 vs DPYD — COAD

Explore this scatter interactively →