Response to erythropoietin

Across TCGA patient cohorts, RNA activity of the Response to erythropoietin pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENM3, CRYBB3, and CHST11, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to erythropoietin activity versus TENM3 in CCRCC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TENM3 →	+0.914	+0.709	.001	.001	3	4
OV	CRYBB3 →	-0.479	-0.519	.005	.008	3	4
LSCC	CHST11 →	+0.531	+0.281	<.001	.001	3	4
GBM	LINC01358 →	+0.258	+0.180	.005	.001	3	4
UCEC	CACFD1 →	-0.778	-0.652	.002	.008	3	4
UCEC	SNX10 →	+0.780	+0.767	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036017 vs TENM3 — CCRCC

Explore this scatter interactively →