Response to interleukin-3

Across TCGA patient cohorts, RNA activity of the Response to interleukin-3 pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-920P, PSIP1, and TVP23A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-3 activity versus RNU6-920P in UCEC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-920P →	+1.057	+0.234	.006	.001	3	4
GBM	PSIP1 →	+0.419	+0.068	.004	.009	3	3
GBM	TVP23A →	+0.652	+0.112	<.001	<.001	3	3
GBM	GNG2 →	+0.781	+0.101	.001	.001	3	3
GBM	RPL5P25 →	+0.264	+0.091	<.001	.005	3	3
GBM	TMPRSS11GP →	+0.444	+0.087	.007	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036015 vs RNU6-920P — UCEC

Explore this scatter interactively →