Protein localization to endosome

Across TCGA cell cohorts, RNA activity of the Protein localization to endosome pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC37A3, ZNF710, and ANXA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC37A3 grouped by Protein localization to endosome-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC37A3 →	+0.803	+0.741	.002	.004	3	6
BONE	ZNF710 →	+1.029	+1.699	<.001	.001	3	5
SKIN	ANXA1 →	-2.181	-0.795	.004	.007	3	5
BLOOD_Leukemia	WASF1 →	+2.203	+1.420	<.001	<.001	3	5
STOMACH	AKT2 →	+0.988	+1.330	.007	.003	2	6
BONE	CREBZF →	+1.745	+2.043	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC37A3 by Protein localization to endosome activity — SKIN

Explore this box plot interactively →