Cellular response to macrophage colony-stimulating factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to macrophage colony-stimulating factor stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, HCLS1, and ARHGAP45, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to macrophage colony-stimulating factor stimulus activity versus RCSD1 in LSCC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.577	+0.091	<.001	<.001	3	9
GBM	HCLS1 →	+0.726	+0.099	<.001	<.001	3	9
LSCC	ARHGAP45 →	+0.514	+0.082	<.001	<.001	3	9
GBM	SKAP2 →	+0.732	+0.087	<.001	<.001	3	8
GBM	STING1 →	+0.536	+0.118	<.001	<.001	3	8
HNSC	TBC1D1 →	+0.364	+0.092	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036006 vs RCSD1 — LSCC

Explore this scatter interactively →