Cellular response to macrophage colony-stimulating factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to macrophage colony-stimulating factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BVES, TLR2, and C3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to macrophage colony-stimulating factor stimulus activity versus BVES in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BVES →	+0.449	+0.795	<.001	<.001	3	4
GBM	TLR2 →	+0.770	+0.293	<.001	<.001	3	4
GBM	C3 →	+1.139	+0.299	<.001	<.001	3	4
HNSC	UBASH3B →	+0.494	+0.743	.003	<.001	3	4
GBM	LILRA1 →	+0.412	+0.271	<.001	.001	3	4
GBM	MPP1 →	+0.458	+0.280	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036006 vs BVES — BRCA

Explore this scatter interactively →