Cellular response to macrophage colony-stimulating factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to macrophage colony-stimulating factor stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTI2, AIF1, and EZH2_T367, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to macrophage colony-stimulating factor stimulus activity versus TTI2 in GBM (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TTI2 →	-0.239	-0.320	<.001	<.001	3	4
GBM	AIF1 →	+0.620	+0.308	<.001	<.001	3	3
OV	EZH2_T367 →	-1.289	-0.724	<.001	<.001	3	3
OV	MORC2_S779 →	-1.304	-0.797	<.001	.005	3	3
PDAC	SEC16A_S1359 →	-1.314	-1.489	<.001	.001	3	3
HNSC	DNAJB5 →	+0.546	+0.688	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036006 vs TTI2 — GBM

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