Cellular response to macrophage colony-stimulating factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to macrophage colony-stimulating factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP4K1, SLC29A2, and HRH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP4K1 grouped by Cellular response to macrophage colony-stimulating factor stimulus-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	MAP4K1 →	+0.537	+1.095	<.001	<.001	3	5
OVARY	SLC29A2 →	+1.547	+0.985	.004	.003	3	5
LIVER	HRH1 →	-2.023	-1.058	<.001	.005	3	5
CNS	KCNN4 →	-1.382	-0.779	.002	.003	3	4
KIDNEY	TLE3 →	+1.104	+1.057	.002	.002	3	4
CNS	C3AR1 →	-0.855	-0.953	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP4K1 by Cellular response to macrophage colony-stimulating factor stimulus activity — CNS

Explore this box plot interactively →