Response to macrophage colony-stimulating factor

Across TCGA patient cohorts, RNA activity of the Response to macrophage colony-stimulating factor pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, OSCAR, and SLC11A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to macrophage colony-stimulating factor activity versus SPP1 in LSCC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SPP1 →	+1.689	+0.643	<.001	<.001	3	8
CCRCC	OSCAR →	+0.766	+0.950	<.001	<.001	3	8
GBM	SLC11A1 →	+1.002	+0.469	<.001	<.001	3	7
GBM	CCL7 →	+1.290	+0.429	<.001	<.001	3	6
BRCA	PLAUR →	+0.929	+1.622	<.001	<.001	3	6
BRCA	CALU →	+0.581	+1.144	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036005 vs SPP1 — LSCC

Explore this scatter interactively →