Response to macrophage colony-stimulating factor

Across TCGA cell cohorts, RNA activity of the Response to macrophage colony-stimulating factor pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf96, EPB41L5, and CCDC117, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C20orf96 grouped by Response to macrophage colony-stimulating factor-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C20orf96 →	+0.688	+1.142	<.001	<.001	3	6
LIVER	EPB41L5 →	+1.478	+1.723	.005	.001	3	6
BLOOD_Leukemia	CCDC117 →	+0.644	+1.302	.002	<.001	3	5
CNS	SNRNP48 →	+0.540	+1.073	.004	.005	3	5
CNS	CNNM3 →	+0.773	+1.125	.002	.004	2	6
CNS	CACNA2D2 →	+0.401	+0.987	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C20orf96 by Response to macrophage colony-stimulating factor activity — BLOOD_Leukemia

Explore this box plot interactively →