Tetrahydrofolate interconversion

Across TCGA patient cohorts, RNA activity of the Tetrahydrofolate interconversion pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DHFR, RFC1, and RFC2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Tetrahydrofolate interconversion activity versus DHFR in LUAD (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DHFR →	+0.516	+0.065	<.001	<.001	3	8
UCEC	RFC1 →	+0.291	+0.076	<.001	<.001	3	7
LSCC	RFC2 →	+0.348	+0.057	<.001	<.001	3	7
UCEC	SMC2 →	+0.609	+0.070	<.001	<.001	3	7
UCEC	SMC4 →	+0.558	+0.065	<.001	<.001	3	7
UCEC	TBL3 →	+0.317	+0.097	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035999 vs DHFR — LUAD

Explore this scatter interactively →