Response to muscle stretch

Across TCGA patient cohorts, RNA activity of the Response to muscle stretch pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH1L1, NME1, and HROB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to muscle stretch activity versus ALDH1L1 in GBM (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ALDH1L1 →	+1.471	+0.151	<.001	.002	3	4
BRCA	NME1 →	-0.585	-0.212	.001	<.001	3	4
BRCA	HROB →	-0.382	-0.114	.003	.009	3	4
GBM	LGI1 →	+0.696	+0.136	.001	<.001	3	3
GBM	CFAP47 →	+0.589	+0.153	.006	.001	3	3
CCRCC	HSD3BP2 →	+0.356	+0.165	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035994 vs ALDH1L1 — GBM

Explore this scatter interactively →