Chondrocyte proliferation

Across TCGA patient cohorts, RNA activity of the Chondrocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DCBLD2, ADAM12, and SPARC, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chondrocyte proliferation activity versus DCBLD2 in PDAC (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	DCBLD2 →	+0.988	+0.324	<.001	<.001	3	9
BRCA	ADAM12 →	+1.522	+0.736	<.001	<.001	3	7
BRCA	SPARC →	+1.269	+0.913	<.001	<.001	3	6
BRCA	TNFAIP6 →	+1.001	+0.842	<.001	<.001	3	6
BRCA	SPOCD1 →	+1.018	+0.825	<.001	<.001	3	6
BRCA	SPOCK1 →	+1.054	+0.651	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035988 vs DCBLD2 — PDAC

Explore this scatter interactively →