Endodermal cell differentiation

Across TCGA patient cohorts, RNA activity of the Endodermal cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL1A1, CCN4, and HMGA2-AS1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endodermal cell differentiation activity versus COL1A1 in GBM (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL1A1 →	+1.888	+0.280	<.001	<.001	3	8
COAD	CCN4 →	+0.604	+0.147	.001	.003	3	8
PDAC	HMGA2-AS1 →	+1.259	+0.223	<.001	<.001	3	7
GBM	COL3A1 →	+1.852	+0.274	<.001	<.001	3	7
LSCC	HMGA2 →	+1.214	+0.289	<.001	<.001	3	6
GBM	COL5A1 →	+1.595	+0.299	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035987 vs COL1A1 — GBM

Explore this scatter interactively →