Cellular response to topologically incorrect protein

Across TCGA patient cohorts, RNA activity of the Cellular response to topologically incorrect protein pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PALM, RPS2, and RPL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to topologically incorrect protein activity versus PALM in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PALM →	+0.700	+0.037	<.001	<.001	3	7
PDAC	RPS2 →	-0.178	-0.021	<.001	<.001	3	7
GBM	RPL3 →	-0.263	-0.031	<.001	<.001	3	6
BRCA	RPL5 →	-0.154	-0.026	<.001	<.001	3	6
LSCC	SYNPO →	+0.273	+0.028	<.001	.001	3	6
BRCA	COL14A1 →	+0.645	+0.028	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035967 vs PALM — BRCA

Explore this scatter interactively →