Cellular response to topologically incorrect protein

Across TCGA pan-cancer cohorts, RNA activity of the Cellular response to topologically incorrect protein pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 109 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Cellular response to topologically incorrect protein pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, KICH, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	IV	0.434	0.207	<.001	58	view →
KICH	DFS	Tertile	II,III,IV	0.502	0.922	.001	43	view →
KIRP	DFS	Median	All	0.366	0.727	.003	39	view →
KIRC	DFS	Median	All	0.527	0.705	<.001	38	view →
LGG	DFS	Median	All	0.773	0.893	<.001	37	view →
SKCM	OS	Median	All	0.944	0.814	.002	26	view →
SCLC	DFS	Median	IV	0.110	0.446	.010	26	view →
MESO	DFS	Tertile	IV	0.120	0.612	.004	20	view →
UVM	DFS	Quartile	III,IV	0.183	1.000	.022	17	view →
ACC	DFS	Tertile	All	0.517	0.779	.023	14	view →
THCA	OS	Tertile	II,III,IV	0.719	0.945	.015	14	view →
BLCA	OS	Median	III,IV	0.509	0.315	.005	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0035967–HNSC (DFS)

Open the HNSC breakdown →