Cellular response to topologically incorrect protein

Across TCGA patient cohorts, RNA activity of the Cellular response to topologically incorrect protein pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRA2, RNF180, and STAG2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to topologically incorrect protein activity versus ANKRA2 in BRCA (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ANKRA2 →	-0.636	-0.127	.001	.001	3	6
LUAD	RNF180 →	-0.788	-0.155	<.001	<.001	3	6
UCEC	STAG2 →	-0.507	-0.215	<.001	<.001	3	5
LSCC	ZNF14 →	-0.400	-0.141	<.001	<.001	3	5
BRCA	SHPRH →	-0.451	-0.133	.007	<.001	2	6
LSCC	ZNF443 →	-0.578	-0.150	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035967 vs ANKRA2 — BRCA

Explore this scatter interactively →