Cellular response to topologically incorrect protein

Across TCGA cell cohorts, RNA activity of the Cellular response to topologically incorrect protein pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP36, PCNX2, and BLCAP, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to topologically incorrect protein activity versus ZFP36 in URINARY_TRACT (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZFP36 →	+1.436	+0.170	.006	.003	1	8
BONE	PCNX2 →	+1.834	+0.181	.007	.003	3	5
LUNG_NSCLC_LUAD	BLCAP →	+0.810	+0.108	.005	.004	2	6
LUNG_SCLC	ANKMY2 →	+0.536	+0.197	.007	.001	3	5
PANCREAS	ATP2C2 →	+2.088	+0.139	.003	.009	3	5
LUNG_NSCLC_LUAD	NMRK1 →	+0.919	+0.114	.004	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035967 vs ZFP36 — URINARY_TRACT

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