Corticosteroid hormone secretion

Across TCGA patient cohorts, RNA activity of the Corticosteroid hormone secretion pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNOT1, RANGAP1, and MCM7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Corticosteroid hormone secretion activity versus CNOT1 in LSCC (Pearson r = -0.07).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CNOT1 →	-0.135	-0.061	.001	<.001	3	6
LUAD	RANGAP1 →	-0.146	-0.052	<.001	.004	3	6
GBM	MCM7 →	-0.477	-0.078	.005	<.001	3	6
LUAD	CASP2 →	-0.289	-0.093	<.001	<.001	3	5
GBM	TPPP3 →	+0.880	+0.072	.003	.001	3	5
CCRCC	DDX10 →	-0.151	-0.053	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035930 vs CNOT1 — LSCC

Explore this scatter interactively →