RNA import into mitochondrion

Across TCGA patient cohorts, RNA activity of the RNA import into mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPD1, MAMDC2, and MARS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA import into mitochondrion activity versus HSPD1 in UCEC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSPD1 →	+0.690	+0.090	.008	.002	3	4
UCEC	MAMDC2 →	-1.377	-0.100	<.001	<.001	3	4
LSCC	MARS2 →	+0.745	+0.140	<.001	<.001	3	4
LSCC	BCL2L12 →	+0.401	+0.113	.006	.001	3	4
LSCC	TRAIP →	+0.658	+0.152	<.001	<.001	3	4
BRCA	FBL →	+0.842	+0.155	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035927 vs HSPD1 — UCEC

Explore this scatter interactively →