RNA import into mitochondrion

Across TCGA cell cohorts, RNA activity of the RNA import into mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TST, RIPOR1, and RAPGEF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA import into mitochondrion activity versus TST in LIVER (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TST →	+1.887	+0.323	.003	.003	2	8
LARGE_INTESTINE	RIPOR1 →	-0.984	-0.254	<.001	<.001	3	6
SKIN	RAPGEF1 →	-0.717	-0.119	.004	.002	3	5
STOMACH	BAIAP2L2 →	+3.481	+0.263	<.001	<.001	3	5
STOMACH	LNPK →	-1.418	-0.287	<.001	<.001	3	5
CNS	SNRK →	-0.624	-0.227	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035927 vs TST — LIVER

Explore this scatter interactively →