Cellular response to vascular endothelial growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to vascular endothelial growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPT1, SNX8, and UQCRQ, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPT1 grouped by Cellular response to vascular endothelial growth factor stimulus-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	JPT1 →	-1.458	-0.258	.001	.008	3	3
STOMACH	SNX8 →	-0.926	-0.270	<.001	.004	3	3
STOMACH	UQCRQ →	+0.901	+0.382	<.001	.001	3	3
STOMACH	POU2F2 →	-1.366	-0.388	.007	<.001	3	3
LUNG_SCLC	ERCC8 →	+1.023	+0.398	<.001	.004	3	3
LUNG_SCLC	EIF5AL1 →	+0.709	+0.316	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPT1 by Cellular response to vascular endothelial growth factor stimulus activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →