Cellular response to vascular endothelial growth factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to vascular endothelial growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANXA1, HSPB1, and CAV1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to vascular endothelial growth factor stimulus activity versus ANXA1 in SOFT_TISSUE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ANXA1 →	+4.346	+0.353	.001	.001	3	9
LARGE_INTESTINE	HSPB1 →	+3.203	+1.337	<.001	.001	3	8
BREAST	CAV1 →	+3.117	+0.336	.001	.004	3	6
BLOOD_Lymphoma	ANXA2 →	+2.478	+1.121	.001	.003	3	6
UPPER_AERODIGESTIVE_TRACT	GLIPR1 →	+2.017	+0.255	.002	.007	3	5
BLOOD_Leukemia	FAM151B →	+0.664	+0.521	<.001	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035924 vs ANXA1 — SOFT_TISSUE

Explore this scatter interactively →