Skeletal muscle cell differentiation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, CCDC85A_S335, and EIF3G, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle cell differentiation activity versus RPL5 in GBM (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.201	-0.038	.001	.004	3	6
LUAD	CCDC85A_S335 →	+0.650	+0.043	<.001	<.001	3	5
OV	EIF3G →	-0.225	-0.026	<.001	.001	3	5
BRCA	LTV1 →	-0.267	-0.021	.003	.004	3	5
BRCA	NIFK →	-0.308	-0.021	.001	<.001	3	5
UCEC	EFHD1 →	+0.372	+0.035	.006	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035914 vs RPL5 — GBM

Explore this scatter interactively →