Dorsal aorta morphogenesis

Across TCGA patient cohorts, RNA activity of the Dorsal aorta morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PCPG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROBO4, PCDH12, and DIPK2B, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal aorta morphogenesis activity versus ROBO4 in PCPG (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PCPG	ROBO4 →	+1.202	+0.054	<.001	<.001	3	33
TGCT	PCDH12 →	+1.436	+0.108	<.001	<.001	3	32
PCPG	DIPK2B →	+1.306	+0.054	<.001	<.001	3	32
MESO	ARHGEF15 →	+1.314	+0.073	<.001	<.001	3	32
KIRC	NOTCH4 →	+1.259	+0.074	<.001	<.001	3	32
LAML	CD34 →	+4.055	+0.121	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035912 vs ROBO4 — PCPG

Explore this scatter interactively →