Dorsal aorta morphogenesis

Across TCGA patient cohorts, RNA activity of the Dorsal aorta morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDF7, ZNF366, and ITM2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal aorta morphogenesis activity versus GDF7 in UCEC (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GDF7 →	+0.730	+0.742	.007	.001	3	4
CCRCC	ZNF366 →	+0.449	+0.353	.001	.002	3	4
UCEC	ITM2A →	+0.896	+0.652	<.001	.001	3	4
COAD	ZNF582-AS1 →	+0.243	+0.717	.003	.001	3	4
GBM	ZNF727 →	+1.476	+0.606	<.001	<.001	3	4
LSCC	LINC01197 →	+0.102	+0.425	.002	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035912 vs GDF7 — UCEC

Explore this scatter interactively →