Aorta morphogenesis

Across TCGA cell cohorts, RNA activity of the Aorta morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARL9, RASGRF2, and ANKHD1-EIF4EBP3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARL9 grouped by Aorta morphogenesis-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	ARL9 →	+0.351	+0.223	<.001	<.001	3	5
KIDNEY	RASGRF2 →	+0.311	+0.194	.005	.005	3	4
OESOPHAGUS	ANKHD1-EIF4EBP3 →	-0.143	-0.127	.002	.007	3	4
BLOOD_Leukemia	AKAP9 →	+0.150	+0.200	.002	.006	3	4
OVARY	RNF144A →	+0.151	+0.144	.001	.006	3	4
CNS	NANP →	+0.345	+0.243	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARL9 by Aorta morphogenesis activity — KIDNEY

Explore this box plot interactively →