Dorsal aorta development

Across TCGA patient cohorts, RNA activity of the Dorsal aorta development pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LAMA4, LAMC1, and NID2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal aorta development activity versus LAMA4 in CCRCC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	LAMA4 →	+0.503	+0.108	<.001	<.001	3	7
BRCA	LAMC1 →	+0.365	+0.038	<.001	<.001	3	7
GBM	NID2 →	+0.396	+0.066	.004	.003	3	7
CCRCC	CLEC3B →	+0.689	+0.087	<.001	.002	3	7
PDAC	ITIH1 →	+0.562	+0.042	<.001	.003	3	7
BRCA	LAMB1 →	+0.321	+0.043	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035907 vs LAMA4 — CCRCC

Explore this scatter interactively →