Aorta development

Across TCGA cell cohorts, RNA activity of the Aorta development pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL1, TARS2, and KLHL12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LOXL1 grouped by Aorta development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LOXL1 →	-0.153	-0.610	.007	<.001	3	5
LARGE_INTESTINE	TARS2 →	-0.321	-1.100	.001	.002	3	4
LUNG_NSCLC_LUAD	KLHL12 →	-0.265	-0.712	<.001	.001	3	4
BLOOD_Myeloma	NME6 →	-0.263	-1.102	.005	.009	2	5
BREAST	PAK4 →	-0.167	-0.748	.007	<.001	3	4
BREAST	GJA4 →	-0.167	-0.590	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LOXL1 by Aorta development activity — BREAST

Explore this box plot interactively →