Aorta development

Across TCGA cell cohorts, RNA activity of the Aorta development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRF1-AS1, PRPF4, and IPPK, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aorta development activity versus IRF1-AS1 in BREAST (Pearson r = -0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IRF1-AS1 →	-0.920	-1.470	.006	<.001	3	6
CNS	PRPF4 →	-0.697	-1.105	.001	.001	3	6
URINARY_TRACT	IPPK →	-0.657	-1.700	.004	.007	3	4
LIVER	MFSD14C →	-0.880	-1.616	.001	<.001	3	4
OESOPHAGUS	TAMM41 →	-0.546	-1.251	.004	.004	3	4
BLOOD_Leukemia	LBH →	-1.692	-0.769	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035904 vs IRF1-AS1 — BREAST

Explore this scatter interactively →