Response to immobilization stress

Across TCGA patient cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERBP1, FRY, and PPP1R13L_S84, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to immobilization stress activity versus SERBP1 in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SERBP1 →	-0.187	-0.054	<.001	<.001	3	5
LSCC	FRY →	+0.227	+0.051	.001	<.001	3	5
LSCC	PPP1R13L_S84 →	-0.586	-0.043	.005	.002	3	5
GBM	EIF2B1 →	-0.155	-0.072	.003	<.001	3	5
LUAD	DYNLT3 →	+0.226	+0.060	.001	.001	3	5
BRCA	SF3B1_S488 →	-0.565	-0.062	.006	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035902 vs SERBP1 — GBM

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