Response to immobilization stress

Across TCGA patient cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNG_T60, RGL1_S520, and SHANK3_S1158, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to immobilization stress activity versus UNG_T60 in OV (Pearson r = -0.06).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	UNG_T60 →	-0.742	-0.244	<.001	<.001	3	3
LSCC	RGL1_S520 →	-0.325	-0.116	<.001	<.001	3	3
UCEC	SHANK3_S1158 →	-0.550	-0.215	<.001	<.001	2	3
OV	CPSF7_S322 →	+1.193	+0.204	.001	<.001	3	2
HNSC	EPB41L1_S430 →	+0.914	+0.276	<.001	.001	3	2
OV	PUS1_S415 →	-0.954	-0.310	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035902 vs UNG_T60 — OV

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