Response to immobilization stress

Across TCGA cell cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOD2, RASD1, and MDM2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOD2 grouped by Response to immobilization stress-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SOD2 →	-0.553	-1.150	.001	.006	3	10
LIVER	RASD1 →	-0.230	-1.221	.001	.004	3	6
SKIN	MDM2 →	-0.909	-1.027	<.001	.003	3	5
OVARY	BCLAF3 →	-0.207	-1.366	.005	<.001	2	6
CNS	TH →	-0.243	-1.076	.003	.005	2	6
LARGE_INTESTINE	ADCY7 →	-0.116	-0.714	.006	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOD2 by Response to immobilization stress activity — STOMACH

Explore this box plot interactively →