Response to immobilization stress

Across TCGA cell cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FDXR, HMGXB3, and SETX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FDXR grouped by Response to immobilization stress-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FDXR →	+1.053	+0.665	<.001	.005	3	4
SOFT_TISSUE	HMGXB3 →	-0.812	-1.058	.003	.006	3	4
LUNG_NSCLC_LUSC	SETX →	-0.691	-1.224	<.001	<.001	3	4
LUNG_NSCLC_LUSC	CIB1 →	-0.837	-1.197	.004	<.001	3	4
LUNG_NSCLC_LUSC	TMEM200B →	-2.139	-1.474	.006	.001	3	4
OESOPHAGUS	SSTR2 →	-0.258	-0.962	.003	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FDXR by Response to immobilization stress activity — SKIN

Explore this box plot interactively →