Response to immobilization stress

Across TCGA cell cohorts, RNA activity of the Response to immobilization stress pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPT2, NDUFAF1, and ZNF365, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to immobilization stress activity versus CPT2 in CNS (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CPT2 →	+0.389	+0.170	.002	.003	2	7
LUNG_NSCLC_LUAD	NDUFAF1 →	+0.415	+0.210	.006	.002	3	5
LIVER	ZNF365 →	-2.119	-0.457	<.001	<.001	3	5
STOMACH	MYO5A →	-2.595	-0.416	.002	.002	3	5
PANCREAS	CPA4 →	-1.947	-0.306	.003	<.001	3	5
STOMACH	CHCHD10 →	+1.531	+0.451	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035902 vs CPT2 — CNS

Explore this scatter interactively →