Enteroendocrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Enteroendocrine cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHANK3, CDH2, and SERPINA7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enteroendocrine cell differentiation activity versus SHANK3 in CCRCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SHANK3 →	+0.373	+0.045	<.001	<.001	3	7
LUAD	CDH2 →	+1.204	+0.069	<.001	<.001	3	6
CCRCC	SERPINA7 →	+0.559	+0.043	<.001	<.001	3	6
CCRCC	BCHE →	+0.389	+0.026	.003	.003	3	6
CCRCC	C8A →	+0.499	+0.038	<.001	<.001	3	6
CCRCC	CFH →	+0.453	+0.033	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035883 vs SHANK3 — CCRCC

Explore this scatter interactively →