Enteroendocrine cell differentiation

Across TCGA pan-cancer cohorts, RNA activity of the Enteroendocrine cell differentiation pathway is associated with patient survival in 29 of 34 cancer lineages. Pathway activity is summarized from the expression of its 35 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Enteroendocrine cell differentiation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and THCA, show the opposite pattern, with higher activity associated with better survival.

UVM, ACC, and MESO are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.899	0.366	.002	35	view →
ACC	DFS	Quartile	IV	0.198	0.710	.006	30	view →
MESO	OS	Tertile	All	0.092	0.558	.008	24	view →
THCA	DFS	Median	All	0.967	0.910	.006	22	view →
PAAD	DFS	Quartile	All	0.468	0.193	.004	21	view →
UCEC	DFS	Quartile	All	0.551	0.809	<.001	18	view →
HNSC	DFS	Median	II,III,IV	0.462	0.277	.008	18	view →
LIHC	DFS	Median	All	0.469	0.604	.001	17	view →
READ	OS	Median	III,IV	0.643	0.981	.001	15	view →
KIRC	DFS	Tertile	All	0.534	0.672	.006	14	view →
LGG	OS	Tertile	All	0.942	0.850	.001	14	view →
UCS	DFS	Tertile	IV	0.860	0.298	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

GO:0035883–UVM (OS)

Open the UVM breakdown →