Enteroendocrine cell differentiation

Across TCGA patient cohorts, RNA activity of the Enteroendocrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHH, ZCCHC12, and LINC02884, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Enteroendocrine cell differentiation activity versus DHH in CCRCC (Pearson r = 0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DHH →	-0.239	-0.302	.003	.006	3	3
CCRCC	ZCCHC12 →	-0.136	-0.253	<.001	.005	3	3
CCRCC	LINC02884 →	-0.503	-0.330	.002	.009	3	3
CCRCC	UNKL →	-0.245	-0.342	.007	.004	3	3
HNSC	HAUS7 →	-0.260	-0.120	.004	<.001	3	3
BRCA	TUBB3P2 →	-0.129	-0.500	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035883 vs DHH — CCRCC

Explore this scatter interactively →