Enteroendocrine cell differentiation

Across TCGA cell cohorts, RNA activity of the Enteroendocrine cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ORC4, CTSH, and FZD3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ORC4 grouped by Enteroendocrine cell differentiation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ORC4 →	-0.947	-1.845	.007	<.001	3	4
BREAST	CTSH →	-1.657	-0.826	.008	.003	3	4
SKIN	FZD3 →	+0.762	+0.959	.002	.004	3	4
SOFT_TISSUE	CEP120 →	-0.673	-1.159	.005	<.001	3	3
SOFT_TISSUE	MED14 →	-0.654	-1.399	<.001	.001	3	3
SOFT_TISSUE	NTF4 →	-1.695	-0.875	.003	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ORC4 by Enteroendocrine cell differentiation activity — BONE

Explore this box plot interactively →