Protein K11-linked deubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K11-linked deubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCF20, DICER1, and BIRC6, each associated with the pathway in up to 33 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K11-linked deubiquitination activity versus TCF20 in DLBC (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TCF20 →	+0.884	+0.073	<.001	<.001	3	33
CHOL	DICER1 →	+1.723	+0.075	<.001	<.001	3	33
DLBC	BIRC6 →	+1.144	+0.072	<.001	<.001	3	33
DLBC	ASH1L →	+1.221	+0.069	<.001	<.001	3	33
DLBC	GON4L →	+1.046	+0.100	.002	<.001	3	33
DLBC	CHD6 →	+1.124	+0.085	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0035871 vs TCF20 — DLBC

Explore this scatter interactively →